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January highlights

The January issue of Ultrasound in Obstetrics & Gynecology is completely free to access and contains 11 Original Articles; an Editorial; two Systematic Reviews; plus a Randomized Controlled Trial


Please see below a selection of articles from the January issue of the Journal chosen specially by the UOG team. To view all UOG content become an ISUOG member today.

Editor’s note

To welcome in the New Year, Editor-in-Chief, Basky Thilaganathan, describes UOG’s admirable achievements in 2015 and introduces readers to the 25th anniversary issue of UOG, packed full of free-access research articles!

View the Editor’s note

  PHYSICIAN ALERT: Zika virus intrauterine infection causes fetal brain abnormality and microcephaly

The recent outbreak of cases of microcephaly in South America has instigated a state of national health emergency and appears to be caused by vertical transmission of the mosquito-borne Zika virus. Oliveira Melo et al. provide evidence of this association in two cases of fetal microcephaly found to be seropositive for Zika virus after sequencing amniocentesis samples.

 View the full article and alert.

How to safeguard competency and training in invasive prenatal diagnosis

Cell-free DNA screening for common autosomal aneuploidies is being introduced increasingly into clinical practice which seems to correspond with a decline in the rate of invasive diagnostic testing. In this Editorial by Hui et al., the effect of declining invasive testing rates is discussed, including its impact on operator experience and, consequently, patient safety.

View the full article    

Topical lidocaine gel and intrauterine lidocaine infusion for pain relief during saline contrast sonohysterography

Saline contrast sonohysterography (SCSH) is used to study the uterine cavity and is well-tolerated by most patients with few adverse effects. However, a number of women experience moderate to severe pain during the procedure, creating a need for effective analgesia. In this randomized, controlled, double-blind trial, topical lidocaine gel and intrauterine lidocaine infusion administered prior to SCSH was evaluated for effective pain reduction during the procedure.

View the full article  

Clinical implementation of routine screening for fetal trisomies in the UK NHS: cell-free DNA test contingent on results from first-trimester combined test

A study by Kypros Nicolaides and his team at King’s College Hospital and King’s College London shows that offering pregnant women a DNA test for Down syndrome on the NHS would reduce the dependency on invasive tests and potentially save the lives of unborn babies.

View the full article and accompanying Journal Club slides

View the press release and commentary from Editor-in-Chief, Basky Thilaganathan.

This month’s Journal Club slides were compiled by Dr Shireen Meher 

Development and validation of a tool incorporating quantitative fetal fibronectin and cervical length to predict spontaneous preterm birth in asymptomatic women

Prediction of preterm birth in women at risk should enable targeted intervention. Assessment of fetal fibronectin and cervical length have superseded previous risk assessments for spontaneous preterm birth (sPTB) in both symptomatic and asymptomatic women. Kuhrt et al. have created a highly accurate algorithm that includes quantitative fetal fibronectin and cervical length measurements to predict sPTB, which has been incorporated into a downloadable App (QUiPP). Further work has been done to update the model for use in symptomatic women, which will be published in next month’s issue.

View the full article and download the App.

Prenatal diagnosis of cobblestone lissencephaly associated with Walker–Warburg syndrome

Cobblestone lissencephaly (CL) refers to the irregular surface of the brain on pathological examination and is considered to be characteristic for a spectrum of recessive autosomal disorders including Walker–Warburg syndrome (WWS), among others. However, WWS is difficult to diagnose prenatally as sonographic features are non-specific and suggestive only in the presence of family history. In a series of four cases of WWS, Lacalm et al. describe a specific prenatal cerebral imaging pattern of CL that enabled a prenatal diagnosis by fetal ultrasound.

View the full article

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