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The May issue of Ultrasound in Obstetrics & Gynecology contains 13 original papers, plus an open-access Editorial focusing on the way in which cfDNA testing is transforming fetal medicine; two free-access Systematic Reviews on the performance of NIPT testing and the accuracy of ultrasound in the diagnosis of vasa previa plus much more supplementary content.

ISUOG News: 06 May 2015

Please see below a selection of free- and open-access articles from the May issue of the Journal specially chosen by the UOG team. To view all UOG content,
become an ISUOG member , today.

Cell-free fetal DNA: the new tool in fetal medicine

An open-access Editorial by Thomas R. Everett and Lynn Chitty explores how the use of cfDNA in fetal medicine has delivered the biggest change in antenatal care over recent decades. With the rapid introduction of new applications for cfDNA in sex determination, detection of aneuploidies and its potential use in the detection of other adverse outcomes such as pre-eclampsia, fetal growth restriction and monogenic disorders, the demand for prenatal testing is increasing. However, as the methods become safer and more efficient there will likely be an impact on training and service provision in order to meet the increase in demand.

View the full article

Cell-free DNA testing: inadequate implementation of an outstanding technique 

Further to this, there is an opinion article by Antoni Borrell and Iosifina Stergiotou addressing some of obstacles that are preventing the more wide-scale use of genomic microarray technology, compared with the rapid update of cfDNA testing that both have the potential to deliver safer and more effective prenatal testing for women. This article is only available to subscribers of UOG; remember to log into the ISUOG website to access this article, or become an ISUOG member to subscribe to UOG.

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Comparative performance of NIPT in high- and low-risk populations

A free-access Systematic Review by Hongyun Zhang et al. compared the clinical performance of NIPT testing for trisomies 21, 18 and 13 in high- and low-risk populations. 146,958 samples were evaluated for immediate clinical performance and validated by long-term follow up of clinical outcomes and karyotyping. The results demonstrated that the performance of NIPT is not compromised in large clinical samples and that the technique can maintain high sensitivity and specificity in screening for trisomy 21 in both low- and high-risk populations.

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Identifying small-for-gestational-age neonates delivering within 2 weeks of assessment

A free-access original article by Kypros Nicolaides and Leona Poon has found that combined testing by maternal characteristics and fetal biometry at 35–37 weeks’ gestation could identify pregnancies that deliver small-for-gestational-age neonates. This method was found to identify 90% (at a 10% false-positive rate) of these pregnancies delivering within just 2 weeks of assessment and 70% of those that deliver after 37 weeks.

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The accuracy of ultrasound in the diagnosis of vasa previa

A Systematic Review by Laura Ruiter et al. has qualitatively evaluated the accuracy of ultrasound in the diagnosis of vasa previa; an obstetric complication that can lead to fetal death or severe morbidity. The findings demonstrate that ultrasound is highly accurate when performed transvaginally in combination with color Doppler.

View the full article and Journal Club slides

This month’s Journal Club slides were compiled by Dr. Katherine Goetzinger












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