This lecture was delivered by Prof. Gianluigi Pilu at ISUOG's intensive course on Fetal anomalies & CNS: Thorax, GIT, GUT, Skeletal System and Syndromes, in February 2014.

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Prof. Gianluigi Pilu (Italy) Past President (2008-2010), ISUOG Fellowship, 2012; Stuart Campbell Award for Education, 2014; Ian Donald Gold Medal, 2007

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