The June issue contains a multicenter screening study on pre-eclampsia that compares performance of the screening model with that of NICE guidelines and ACOG recommendations and five articles on non-invasive prenatal testing, including an Editorial and updated ISUOG Consensus Statement on cfDNA screening for aneuploidy.
Please see below a selection of articles from the June issue of the Journal chosen specially by the UOG team. To view all UOG content become an ISUOG member today.
ISUOG updated consensus statement on the impact of cfDNA aneuploidy testing on screening policies and prenatal ultrasound practice
The range of cell-free DNA (cfDNA)-based screening techniques for aneuploidy has expanded over the last few years, with cfDNA tests being incorporated rapidly into prenatal care and, consequently, changing the approach to prenatal screening and diagnosis. Their role alongside other screening modalities must be considered however, specifically prenatal ultrasound. In this updated consensus statement, the ISUOG Clinical Standards Committee provide a revised and updated version of the previously published ISUOG consensus statement on the impact of non-invasive prenatal testing on prenatal ultrasound practice.
View the ISUOG Consensus Statement
Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation: comparison with NICE guidelines and ACOG recommendations
The traditional approach to screening for pre-eclampsia (PE) is to determine risk factors from maternal characteristics and medical history. The National Institute for Health and Care Excellence (NICE) recommends women should be considered at high risk of developing PE if they have at least one high-risk factor or at least two moderate-risk factors. In the USA, the American College of Obstetrics and Gynecologists (ACOG) recommend taking a medical history to determine risk factors as the only screening approach for PE. In a new multicenter screening study of 8775 singleton pregnancies, O’Gorman et al. examined the performance of screening for PE at 11–13 weeks based on risk factors from medical history, as recommended by NICE and ACOG, with the method proposed by The Fetal Medicine Foundation, which uses an algorithm to calculate the patient-specific risk.
View the full article and accompanying Journal Club slides compiled by Dr Fiona Brownfoot.
Discrimination of adnexal masses using the IOTA ADNEX model
In this issue of UOG are two articles describing the external validation of the IOTA ADNEX model for determining malignancy in adnexal masses. In the first study by Araujo et al., the performance of the ADNEX model in the preoperative discrimination between benign ovarian tumors, borderline ovarian tumors, Stage I ovarian cancer, Stage II–IV ovarian cancer and ovarian metastasis was evaluated in 131 women attending a gynecological oncology center in Brazil. In the second study by Meys et al., the performance of the ADNEX model was compared with other frequently used models in the differentiation between benign and malignant adnexal masses in 326 women.
Physical models of monochorionic diamniotic quadruplet pregnancy from prenatal three-dimensional ultrasound and magnetic resonance imaging
Monozygotic twinning is relatively rare after natural conception and the rate after assisted reproductive technology (ART) is estimated at 2–12 times higher. Simultaneous division of two transferred embryos in ART is even rarer, and embryo reduction is performed in most cases. Using data from prenatal ultrasound and magnetic resonance imaging, Werner et al. produced three-dimensional physical and virtual models of a quadruplet pregnancy, consisting of two sets of monochorionic diamniotic twins.
View the full article here.
Coming up in the next issue of UOG…
• A systematic review and meta-analysis by Bittencourt et al. on the accuracy of saline contrast sonohysterography in detecting endometrial polyps and submucosal leiomyomas in women at reproductive age with abnormal uterine bleeding. Preview the accepted article here. This article has been chosen for Journal Club, so look out for the accompanying downloadable slides next month.
• Ludwin et al. provide step-by-step guidance, including downloadable PowerPoint slides, for a simple and novel technique to assess uterine cavity volume and shape using sonohysterography and automatic volume-calculation software. Preview the accepted article here.
• An Editorial by Tutschek et al. on three-dimensional ultrasound imaging of the fetal skull and face, including many extra images that are provided online. Preview the accepted article here.