First and second branchial arch anomalies

Treacher Collins syndrome (TCS) or mandibulofacial dysostosis is a rare, autosomal dominant genetic syndrome characterized by typical abnormalities of the bony structures of the face that, if severe, can lead to breathing and feeding difficulties at and after birth.

Oculo-auriculo-vertebral spectrum (OAVS), which includes Goldenhar syndrome and hemifacial microsomia, is a rare developmental disorder typically characterized by congenital anomalies of the mouth, ears, eyes, and vertebrae.